The Iguana/DZIP protein controls biogenesis of primary cilia
نویسندگان
چکیده
منابع مشابه
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis
Defects in cilia centrosomal genes cause pleiotropic clinical phenotypes, collectively called ciliopathies. Cilia biogenesis is initiated by the interaction of positive and negative regulators. Centriolar coiled coil protein 110 (CP110) caps the distal end of the mother centriole and is known to act as a suppressor to control the timing of ciliogenesis. Here, we demonstrate that CP110 promotes ...
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As essential components of the eukaryotic cytoskeleton, microtubules fulfill a variety of functions that can be temporally and spatially controlled by tubulin posttranslational modifications. Tubulin glycylation has so far been mostly found on motile cilia and flagella, where it is involved in the stabilization of the axoneme. In contrast, barely anything is known about the role of glycylation ...
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The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2009
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.05.372